cenobamate will enhance the level or effect of diazepam by influencing hepatic enzyme CYP2C19 metabolism. Modify Therapy/Monitor Intently. Contemplate a dose reduction of CYP2C19 substrates, as clinically suitable, when used concomitantly with cenobamate.Impact of coadministration of the twin CYP3A4 and CYP2C19 inhibitor with fedratinib hasn't been